Thursday, May 04, 2006










V. Trigeminal Nerves


www.umanitoba.ca/cranial_nerves/trigeminal_neuralgia/manuscript/images/tncomp.jpg


-3 Divisions: Ophthalmic (V1), Maxillary (V2) and Mandibular (V3)
-The main functions of the trigeminal nerves are sensing facial touch, pain and temperature and controlling muscles used for chewing.



1) Ophthalmic Divison (V1)
-leaves the neurocranium through the superior orbital fissure of the sphenoid bone
-travels to the forehead and eye
-Sensory neurons send sensory info from the following targets: anterior scalp, upper eyelid, nose, mucous membrane of nose, cornea and lacrimal (tear) gland.

2) Maxillary Divison (V2)
-leaves the neurocranium through the foramen rotundum of the sphenoid bone
-travels to the cheek
-Sensory neurons send sensory info from the following targets: mucous membrane of nose, palate, upper teeth, skin of cheek, upper lip and lower eyelid.

3) Mandibular Division (V3)
-leaves the neurocranium through the foramen ovale of the sphenoid bone
-travels to the lower face and jaw
-Sensory neurons send sensory info from the following targets: anterior tongue (excluding the taste buds), lower teeth, skin of chin, and temporal area of scalp.
-Motor neurons send info to the following targets: muscles of mastication, which are muscles involved in chewing.


Regions each division innervates:





www.umanitoba/ca/cranial_nerves/trigeminal_neuralgia/manuscript/images/tndistr.jpg


Saturday, April 08, 2006


The Upper Limb


www.fotosearch.com/comp/BDX/BDX199/bxp36248.jpg



Bones and Joints of the Upper Limb
The upper limb is attached to the axial skeleton at the shoulder joint, which is a ball and socket joint, joining the scapula and the humerus (the only bone of the arm). Moving distally, the next joint is the elbow joint. It is a hinge joint that connects the humerus to the 2 bones of the forearm, the radius and the ulna. These 2 bones are long parallel bones and the radius attaches on the thumb side of your hand. There is a proximal and a distal radioulnar joint that connects the radius and the unla. It is a pivot joint allowing for rotation, pronation and supination of the forearm (twist your arm so your palms are up = supination and then twist so the palm is down = pronation). The wrist joint connects the ulna/radius to the carpals, then the carpals to the metacarpals. The wrist joint is a plane joint. A condyloid joint, named the metacarpal-phalangeal joint, connects the metacarpals to the phalanges. The interphalangeal joint (IP), a hinge joint, connects the phalanges to each other. Finally, a saddle joint joins the metacarpals and carpals at the thumb.





Bones of the upper limb

www.cmki.org/images/HWAS2.gif



-All of the joints of the upper arm are synovial joints which contain lubricating syonvial fluid.




Synovial joint
http://training.seer.cancer.gov/module_anatomy/images/illu_syonvial_joint.jpg




-The ends of the bones are covered in articular (hyaline) cartilage, which help absorb compression in the joints.
-Each bone is made up of compact bone and spongy bone. The outside layer is the compact bone and the inside is spongy bone.
-Spongy bone is a honeycomb of small pieces called trabeculae.



Spongy bony tissue
www.engr.smu.edu/~jll/Imge7.gif


-Compact bone is made up of long parallel cylinders called the Haversian system.










Compact Bony tissue
www.gwc.maricopa.edu/class/bio201/histoprc/bon2_s.jpg









-Nerves and blood vessels pass through the passageways of compact bone and the trabeculae spaces of spongy bone.



Muscles of the Upper Limb
There are 9 muscles that insert (where it attaches on a movable bone) on the humerus, but only 3 of these muscles actually help to move the upper limb. The 3 muscles are the pectoralis major, latissimus dorsi and the deltoids. Of the remaining six muscles, 4 of them make up the rotator cuff, which help reinforce the shoulder joint. The last 2, cross at the shoulder, one of which is the teres major. Of these 9 muscles, the ones that originate (where it attaches to a less movable bone) on the anterior side of the shoulder joint (pectoralis major, anterior deltoids) move the upper limb to flex. The biceps in the arm also flex the upper limb. Muscles that originate posterior to the shoulder joint extend the upper limb. They include the latissimus dorsi and posterior deltoids. Also, the triceps are extensor muscles.

The forearm muscles move the wrist and also move the fingers and thumb. The muscles on the anterior side help flex and pronate, while the posterior muscles are responsible for extension and supination.






Major muscles of upper limb
www.interwood.com/a/p/slendertone/fortex/muscles.jpg


-All of these muscles are made of skeletal muscle tissue.
-Skeletal muscle fibers are long and striated.
-Skeletal muscle is considered voluntary muscle because it is under conscious control.
-Skeletal muscle is accountable for body movement.



Skeletal muscle tissue
www.waycross.edu/faculty/bmajdi/skeletal%20muscle%202.jpg



Nerves that trigger the muscles to move the skeleton
Motor neurons are found in the ventral horn of the spinal cord. The motor neuron then follows the ventral root out of the ventral horn. Where the ventral root meets the dorsal root, a spinal nerve is formed. A nerve is a parallel bundle of peripheral axons. After the spinal nerve exits the vertebral column through the intervertebral foramen, it splits into ventral and dorsal ramus. The ventral rami form the brachial plexus that innervates the upper limb.











Brachial Plexus
depts.washington.edu/anesth/region/plexusdiagram.gif


The axon of each motor neuron divides as it enters the muscle. Each axonal ending forms a neuromuscluar junction with a single muscle fiber. A motor unit is one motor neuron and the muscle cells it synapses with.

An action potential is generated when a neuron is stimulated. The electrical impulse is conducted along the neuron’s axon (which has an insulating myelin sheath formed by Schwann cells) when Na+ influxes and diffuses along the axolemma. As the electrical impulse arrives at the synapse between the nerve and the muscle, calcium channels are opened and Ca2+ enters, which trigger the muscles to contract. Contraction is the sliding of two myofilaments, actin and myosin.








Actin-myosin filaments contracting

www.carolguze.com/images/cellorganelles/actin-myosin.jpg







When the muscles contract, they pull on the tendons to move the bones at the joints.

The 4 major nerves from the brachial plexus that innervate the upper limb are the musculo-cutaneous nerve, ulnar nerve, median nerve (all innervate the anterior division) and the radial nerve (which innervates the posterior division).









www.cmki.org/images/HWAS4.gif

Thursday, March 16, 2006



Topic of discussion: How the peripheral nerves fit in with the vertebral column.

Let’s start with the vertebral column and the structure of the vertebrae.

Vertebral Column Characteristics
-otherwise known as the spine
-made up of 26 irregular bones
-it is curved and flexible
-it starts at the skull and extends to the pelvis
-surrounds and protects the spinal cord
-ribs and muscles of the back and neck attach to it
-the sacrum and the coccyx are fused vertebrae, while the other 24 are separated by intervertebral discs.


www.academic.kellog.edu/herbrandsonc/bio201_McKinley


Divisions and Curvatures
The five major divisions are:
1. Cervical vertebrae, C1-C7 (seven vertebrae of the neck)
2. Thoracic vertebrae, T1-T12 (next 12 vertebrae)
3. Lumbar vertebrae, L1-L5 (5 vertebrae supporting the lower back)
4. Sacrum, S1-S5 (5 fused vertebrae)
5. Coccyx (terminus of the vertebral column, aka the tailbone)

The spine is curved like and “S”: the cervical and lumbar curvatures are concave and the thoracic and sacral curvatures are convex. This helps make the spine flexible.

Intervertebral Discs

-nucleus pulposus is the inner part of the disc. It makes the disc elastic and compressible.
-annulus fibrosus is the strong stuff surrounding of the nucleus pulposus. It is made up of collagen fibers and fibrocartilage.
-intervertebral discs act as shock absorbers and allow the spine to bend and flex.

www.courses.vcu.edu



Structure of Vertebrae
-each has an anterior body (centrum) and a posterior vertebral arch.
-the body is disc shaped and it is the weight-bearing part.
-vertebral foramen is the opening surrounded by the body and arch.
-the spinal cord passes through the vertebral foramen and when stacked upon one another, it is called the vertebral canal.
-the vertebral arch is made up of 2 pedicles, and 2 laminae. The pedicles form the sides of the arch and the laminae complete the posterior side of the arch.
-there are 7 processes that project from the arch:
∙The spinous process and the transverse process are where muscles and ligaments attach.
∙A pair of superior articular processes and a pair of inferior articular processes form movable joints.
∙Intervertebral foramina are lateral openings between vertebrae, which is where the spinal nerves exit the vertebral column.

www.webschoolsolutions.com/patts/systems/vertebra


Moving on to the Peripheral Nerves……

2 Main parts of the Nervous System are:
-Central Nervous System (CNS) is the brain and spinal cord
-Peripheral Nervous System (PNS) is made up mostly of nerves that extend from the brain and the spinal cord.

Peripheral nerves carry messages to and from the CNS to all parts of the body.

2 Main parts of the PNS are:
Sensory (afferent) division:
-carries impulses from sensory receptors in the body to the CNS
-somatic sensory nerve fibers and visceral sensory nerve fibers
Motor (efferent) division:
-carries impulses from CNS to muscles and glands (effector organs)
-Motor division can be further divided into:
Somatic Nervous System – voluntary
-Carries impulses from CNS to skeletal muscles
Autonomic Nervous System – involuntary
-carries impulses from CNS to cardiac and smooth muscles, glands
-can be sympathetic (aka “fight or flight”) or parasympathetic (aka “resting and digesting”)

Neuroglia in PNS:
-Satellite cells: surround neuron cell bodies, function is unknown
-Schwann cells: insulate and form myelin sheaths around nerve fibers, vital to regeneration of nerve fibers
www.steve.gb.com

Neurons (nerve cells):
-structural units of nervous system
-conduct nerve impulses
-neurons can live for a very longtime, given the right conditions
-amitotic, meaning they can’t divide, therefore they can’t be replaced
-require lots of oxygen and glucose

www.home.ubalt.edu

Structure of a neuron:
Cell body (soma) - has a clear, round nucleus and most cell bodies are located in the CNS
Processes – arm-like extensions of the cell body. The PNS is mostly processes.
2 types of processes: dendrites and axons

Dendrites
-short, tapering, and diffusely branching = many per neuron
-bring incoming messages towards cell body

Axons
-one per neuron
-can be short or really, really long
-generates nerve impulses and transmits them away from cell body
www.fusionanomaly.net/dendrite

Nerves:
-cordlike organ made up of a parallel bundle of peripheral axons wrapped in 3 layers of connective tissue: endoneurium, perineurium and epineurium.
-classified by the direction in which they transmit impulses
Sensory (afferent) nerves – carry impulses to CNS
Motor (efferent) nerves – carry impulses from CNS
Mixed nerves – have both sensory and motor fibers
-peripheral nerves are classified as cranial or spinal
-Spinal nerves carry impulses to and from the spinal cord and cranial nerves carry impulses to and from the brain.

Spinal Nerves
-31 pairs with each made up of thousands of nerve fibers
-come from the spinal cord and go to all parts of the body except the head and some parts of the neck
-all are mixed nerves
-8 pairs of cervical nerves (C1-C8)
-12 pairs of thoracic nerves (T1-T12)
-5 pairs of lumbar nerves (L1-L5)
-5 pairs of sacral nerves (S1-S5)
-1 pair of coccygeal nerves (C0)
*there are 8 pairs of cervical nerves even though there are only 7 cervical vertebrae….the first 7 pairs exit superior to the vertebrae. Afterwards, all other spinal nerves exit inferior to the vertebrae.



www.spineuniverse.com
www.becomehealthynow.com


Structure of the spinal nerve
-a dorsal root and a ventral root connect each spinal nerve to the spinal cord
-dorsal roots have sensory (afferent) fibers while ventral roots have motor (efferent) fibers
-spinal roots come out of the cord laterally and both roots unite to form the spinal nerve
-roots from the lumbar and sacral areas extend inferiorly through the cauda equina before they exit the vertebral column
-spinal nerves are short and after emerging from the intervertebral foramen, divide into dorsal ramus, ventral ramus and meningeal branch
-each ramus is made up of mixed nerves

Ventral rami branch and then form nerve plexuses that innervate the body.
There are cervical, brachial, lumbar and sacral plexuses.

Dorsal rami innervate the back by following the strip of muscle that is located in line with where it exits the vertebral column (so it follows the segmentation format!).
www.training.seer.cancer.gov

Tuesday, February 07, 2006

Epithelial Tissue: Sheet of cells that covers the body or lines a body cavity.
Can be separated into two basic overall types: a) covering and lining epithelia and b) glandular epithelia.

Special Characteristics of Epithelium include cellularity (made of close packed cells leaving very little extracellular material), specialized contacts (i.e. tight juctions and desmosomes), polarity (free apical surface and attached basal surface), supported by connective tissue (all epithelial sheets rest upon connective tissue), avascularity (contains no blood vessels) and regeneration (has a high capacity to regenerate).

Classification of Epithelial Tissue
A) Covering and Lining Epithelia
1. Simple Squamous Epithelium
-Squashed cells in a single thin, permeable layer with very little cytoplasm.
-Nuclei are centered and disc-shaped.
-Its function is to filter or rapidly diffuse substances.
Ex: lining of the heart


Simple Squamous Epithelium (www.technion.ac.il)


2. Simple Cuboidal Epithelium
-Cube shaped cells in a single layer.
-Nuclei are centered and spherical.
-Its function is to absorb and secrete.
Ex: kidney tubules



Simple Cuboidal Epithelium (www.technion.ac.il)



3.Simple Columnar Epithelium
-Single row of tall, column-like cells.
-Nuclei are round.
-Cilia may be present.
-Its function is to absorb and secrete.
-Secretes mucus.
-Cilia movement propels substances and cells.
Ex: lining of digestive tract


Simple Columnar Epithelium (www.technion.ac.il)


4. Pseudostratified Columnar Epithelium
-Column shaped cells in a single layer, but all vary in height.
-Cilia may be present.
-Its function is to secrete and absorb.
Ex: lining of respiratory tract





Pseudostratified Epithelium (http://erl.pathology.iupui.edu/HISTO/GENER60.HTM)





5. Stratified Squamous Epithelium
-Several layers of cells thick.
-The top layer is squamous cells and the deeper layers are cuboidal or columnar cells.
-Its function is to protect underlying tissues in areas of the body that are subjected to abrasion.
Ex: Epidermis




Stratified Squamous Epithelium (www.visualsunlimited.com)









6. Stratified Cuboidal Epithelium
-Two layers of cuboidal cells
Ex: mammary glands



Stratified Cuboidal Epithelium (www.keele.ac.uk)






7. Stratified Columnar Epithelium
-Apical layer is columnar cells.
Ex: pharynx



Stratified Columnar Epithelium (www.anatomy.dal.ca)





8. Transitional Epithelium
-Basal layer is cuboidal or columnar.
-Apical layer varies, depending upon how distended the area is.
-Its function is to stretch to allow distension.
Ex: lining of the urinary bladder





Transitional Epithelium (www.faculty.une.edu)





B) Glandular Epithelia
1. Endocrine Glands
-Ductless glands.
-Produce hormones, which secrete into extracellular space, then into blood and then travel to specific

organs to increase response.
-Secretions vary from amino acids to steroids.
Ex: adrenal gland
2. Exocrine Glands
-Have ducts.
-Secrete products onto skin or into body cavities
Ex: mucous glands
a. Unicellular Exocrine Glands
-one celled
Ex: Goblet cell in intestinal and respiratory tracts
b. Multicellular Exocrine Glands
-many celled
-have an epithelium-based duct and a secretory unit
1. Simple Multicellular Exocrine Glands
-unbranched duct
2. Compound Multicellular Exocrine Glands
-branched duct
3. Tubular Multicellular Exocrine Glands
-Secretory cell forms tubes
Ex: Intestinal glands
4. Alveolar Multicellular Exocrine Glands
-Secretory cells form small sacs
Ex: Mammary glands
5. Tubuloalveolar Multicellular Exocrine Glands
-both types of secretory units
Ex: Salivary glands

Connective Tissue: Most abundant tissue and it is found everywhere in the body.
It functions to bind and support, protect, insulate and transport (in the case of blood).

Special Characteristics of Connective Tissue include that it originates from mesenchyme, has a full range of vascularity, it is mainly composed of extracellular matrix (which gives it the ability to endure weight, tension, trauma and abrasion). The extracellular matrix is made up of ground substance and fibers (collagen, elastic or reticular).

Types of Connective Tissue
1. Mesenchyme (Embryonic Connective Tissue)
-First tissue formed from mesoderm
-Made up of mesenchymal cells and fluid ground substance with fibrils
-specializes into all other types of connective tissue.
2. Connective Tissue Proper
A. Loose Connective Tissue
1. Areolar Connective Tissue
-Most abundant connective tissue
-Binds body parts together, but allows for movement of these parts.
-It is wrapped around small blood vessels,nerves and glands.
-Makes up the subcutaneous tissue that cushions and attaches the skin to structures.
-Defends against infection.
-Stores nutrients as fat.
-Ex: lamina propria of mucous membranes


Areolar Connective Tissue (www.science.tjc.edu)





2. Adipose (Fat) Tissue
-Makes up 18% of average person’s body weight.
-Very vascular, indicating high metabolic activity.
-Functions as a shock absorber and insulation. Also prevents heat loss.
Ex: Abdomen


Adipose Tissue (www.science.tjc.edu)



3. Reticular Connective Tissue
-Reticular fibers are the only fibers in the matrix
-Forms a stroma that supports free blood cells (mainly lymphocytes)
Ex: lymph nodes



Reticular Connective Tissue (www.udel.edu)




B. Dense Connective Tissue
1. Dense Regular Connective Tissue
-Made up of dense collagen fibers running parallel to the direction of pull.
-Its function is to attach muscles or bones to bones.
-Has high tensile strength in one direction.
Ex: Tendons




Dense Regular Connective Tissue (www.pathology.mc.duke.edu)



2. Dense Irregular Connective Tissue
-Collagen fibers run in more than one plane.
-Has high tension strength in more than one direction.
Ex: Dermis of the skin




Dense Irregular Connective Tissue (www.sru.edu)












Thursday, February 02, 2006

Organization of the Human Body

The organization of the Human body can be broken down into 6 levels of structural organization:

1. Chemical level: This is where atoms form molecules. The four molecules of life are proteins (catalyze chemical reactions), lipids (form cell membrane), carbohydrates (supply fuel) and DNA & RNA (responsible for the genetic code). Molecules form organelles, which are the basic components of cells.
2. Cellular level: Cells are the basis of all living things. Cells vary in function, shape & size, but have the same basic parts, such as the plasma membrane, cytoplasm, organelles, and the nucleus. DNA replication allows cells to divide which then allows for body growth and tissue repair.
3. Tissue level: Similar cells with a common function group together to form tissues. Each of the four basic tissue types has a specific role in the body. The epithelium tissue covers the body surface and lines its cavities, muscle tissue provides movement, connective tissue supports and protects organs and nervous tissue provides internal communication.
4. Organ level: When 2 or more tissue types combine to form a structure that has a specific function in the body.
5. Organ system: This is made up of organs and structures that work together to perform a specific function. Organ systems of the body include cardiovascular, integumentary, skeletal, muscular, nervous, endocrine, respiratory, digestive, lymphatic, urinary and reproductive.
6. Organism level: When the entire body is working together to promote life.

Fetal Development
The gestation period of a fetus is about 280 days. The following outlines the steps of fetal development.

Fertilization
1. Sperm must reach the ovulated secondary oocyte and must undergo capicitation. Hundreds of sperm must also undergo the acrosomal reaction to expose the oocyte membrane so that one sperm can make contact.
2. Polyspermy is prevented in humans by Na+ diffusing into the oocyte after one sperm enters. This causes depolarization of the membrane. The cortical reaction also stops more sperm from entering by destroying sperm receptors.
3. The sperm loses its tail and midpiece. The ovum and sperm pronuclei rupture and release their chromosomes near the mitotic spindle. Fertilization occurs as these chromosome combine and form a zygote (a fertilized egg).
Preembryonic Development
1. After fertilization, cleavage produces two identical cells called blastomeres. These continue to divide and produce more cells until it reaches about 100 cells. Now it is called a blastocyst.
2. The blastocyst has a single layer of flattened cells, called trophoblast cells, which eventually form the placenta. It also has a small cluster of rounded cells, called the inner cell mass, which becomes the embryonic disc and then later becomes the embryo.
Implantation
1. The blastocyst implants into the endometrium about 6 to 7 days after ovulation. It is covered over and sealed off from the uterine cavity.
Placentation
1. The placenta is formed from the trophoblastic and maternal endometrial tissues.
2. The trophoblast gives rise to a layer of extra embryonic mesoderm on its inner surface, this becomes the chorion. The chorion develops chorionic villi which become the umbilical arteries and vein.
3. The placenta is a temporary organ and it detaches and sloughs off after the infant is born.
Embryonic Development
1. The blastocyst is a 2 layered flat sheet of germ cells (also called stem cells).
2. The embryonic membranes formed during the first 2 to 3 weeks include the amnion (which becomes filled with amniotic fluid), the yolk sac (which forms part of the digestive tube, produces the earliest blood cells and blood vessels, and seeds the gonads), the allantios (which becomes the umbilical cord) and the chorion (which helps form the placenta).
Gastrulation
1. During week 3, the 2 layered embryonic disc becomes a 3-layered embryo. The 3 layers are the primary germ layers, the ectoderm, endoderm and mesoderm.
2. Formation of the primitive streak, a raised groove on the dorsal surface of the embryonic disc, starts gastrulation.
3. The notochord forms the first axial support of the embryo and later it becomes the vertebral column.
Organogenesis
Formation of the body organs and organ systems.
a.
Specialization of the Ectoderm
1. Neurulation-formation of neural tube, which eventually becomes the brain and spinal cord.
2. The ectoderm will eventually form the structures of the nervous system and the skin epidermis.
b. Specialization of the Endoderm
1. Flat plate of cells folds to form a cylindrical body, with two tubes. The inner tube is the endoderm tube, which is the primitive gut. It will eventually form the lining of the gastrointestinal tract.
c. Specialization of Mesoderm
1. Somites are formed to produce vertebra, ribs, dermis of the skin on the dorsal side, and the skeletal muscles and muscles of the limbs.
2. Intermediate mesoderm forms the gonads and kidneys.
3. Lateral mesoderm forms the dermis of the skin on the ventral part of the body and the parietal serosa and visceral serosa. The celum is the part in between the parietal and visceral serosa. It produces bones, ligaments and dermis of limbs.
4. Sphlanchnic mesoderm forms the heart and blood vessels and connective tissues. It also forms the entire wall of the digestive and respiratory organs.
Fetal Circulation
1. The cardiovascular system is the groundwork for the fetal circulatory system.
2. Endothelial cells form vascular networks, which later become the heart, blood vessels, and lymphatics.
3. The umbilical arteries, ductus venosus, foramen ovale and ductus arteriosus are only present during fetal development and are occluded at birth.

Monday, January 23, 2006

1. Melissa Coles
2. Melrose, MA
3. Dave Matthews Band
4. Applied for Clinical Lab Science Program
5. I am married and I have a 6 month old son.

Digital Native Score: 7